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Background: Pharmacological research on Ajuga integrifolia has previously shown that it has antimalarial, anti-diabetic, antioxidant, anti-inflammatory, and anticonvulsant properties. A. integrifolia was one of the traditional plants which are believed to have analgesic properties, particularly for stomach aches. However, its analgesic and anti-pyretic activity hasn`t been studied yet.
Objective: To evaluate analgesic and antipyretic activities of 70% ethanol extract of A. integrifolia (EEAI) leaf in mice.
Methods: The Eddy's hot plate technique was used to evaluate the extract's central analgesic activity, while the acetic acid-induced writhing test was used to measure its peripheral analgesic activity. In mice, the antipyretic activity of the extract was investigated by inducing pyrexia using Brewer's yeast.
Results: The study investigated the effects of different doses of ethanol extracts from A. integrifolia leaves. The doses administered were 100, 200, and 400mg/kg orally. The study was found that ethanol extracts exhibited a significant analgesic effect in a dose-dependent manner when assessed using the hot plate method. At 90 minutes, the respective doses resulted in latency responses of 42.20%, 58.71%, and 66.77%. The extracts also showed the ability to reduce acetic acid-induced writhing in mice at all tested doses. Furthermore, the extracts caused a significant decrease in the subjects' rectal temperature at doses of 100, 200, and 400 mg/kg. These effects are likely due to the presence of various compounds such as phenols, flavonoids, tannins, saponins, alkaloids, and terpenoids, which may inhibit prostaglandin release pathways.
Conclusion: The findings of this study not only confirm the traditional claims associated with the plants but also offer insights that can guide future investigations of the plant. These discoveries have the potential to contribute to the development of analgesic and antipyretic medications that are both effective and safe. |
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