HIV is a major global public health issue, having claimed 38 million lives so far.Ethiopia is one of the most seriously affected countries in sub-Saharan Africa, with many people living with HIV/AIDS. HIV infection in health care facilities has become a significant health problem, especially in resource-poor settings.Health care workers are at risk of many diseases in health setups. There is a small but definite occupational risk of HIV transmission to health care workers. PEP is recommended to prevent the transmission of pathogens after potential exposure and further development of infection.If started soon after exposure, PEP can reduce the risk of HIV infection by over 80%.Although studies have found that awareness of PEP, no publication assesses utilization practice and subsequent follow-up in our institution.