Diabetes is a growing public health challenge worldwide, including Ethiopia. Comprehensive multifactorial cardiovascular risk reduction is recommended to reduce diabetes-associated morbidity and mortality but achieving the triplet goals (optimization of blood glucose, blood pressure and low density lipoprotein levels) remained a global clinical challenge. Patients’ knowledge of these therapeutic goals of diabetes care contributes to improved self-care and glycemic control. However, the patients’ knowledge of the therapeutic goals in diabetes and its determinants have not been studied comprehensively in Ethiopia.