Job stress is a prevalent problem among nurses working in cancer units as they deal with a large number of patients with various conditions and work overload. Therefore, if it is not properly managed stress leads to high levels of employee illness, absenteeism, high turnover, and decreased productivity which compromises the provision of quality service to clients. Coping is a cognitive and behavioral effort one uses to face a stressful situation. There is no recorded data on job stress and coping strategies in our country specifically in the cancer unit. Objective: To assess job stress, coping strategy, and associated factors among nurses working in cancer units of selected governmental hospitals at Addis Ababa, Ethiopia, 2020.